19 Jan Although in the present case contributory factors such as
Social networking has taken off in a massive way. Look at the success of Facebook and Orkut and you’ll understand what I mean. Organizations struggle to use social networking to impart employee training. The association of Addison’s disease with thyroiditis is known as Schmidt’s syndrome and is a common manifestation of type 2 polyglandular autoimmune syndromes.7View this table:View inlineView popupTable 1Features and treatment of Addison’s diseaseHypoglycaemia is not a common presenting feature of Addison’s disease, either in patients with type 1 diabetes or in the non diabetic population pandora charms, although it has been reported to be associated both with primary and secondary glucocorticoid deficiencies,89 and is considered to be caused by enhanced insulin sensitivity. Diminished secretion of other counter regulatory hormones may also contribute and a combination of cortisol and growth hormone deficiencies has been associated with profound hypoglycaemia in diabetic patients treated with insulin.8The much more common factors of excessive insulin, insufficient carbohydrate, and exercise that precipitate or predispose to acute hypoglycaemia in patients with type 1 diabetes, must not be overlooked despite evidence of glucocorticoid deficiency. Although in the present case contributory factors such as excessive alcohol consumption and delayed ingestion of meals could be identified in a few of the episodes of severe hypoglycaemia, the recurrence of severe hypoglycaemia in conjunction with a decline in total insulin dosage was suggestive of another underlying pathogenetic problem, unassociated with the patient’s self management of his diabetes.The classical features of adrenal failure such as anorexia, lethargy, and weight loss with deranged plasma electrolytes, were not prominent in the present case until the patient presented in adrenal crisis, although signs of hypotension, hyperpigmentation and vitiligo (which occurs in 4% 17% of patients with autoimmune Addison’s disease) had been noted.
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